Dr. Christian Roberts leads the Exercise and Metabolic Disease Research Laboratory (EMDR), which investigates the role of exercise training and diet in the development and prevention of metabolic diseases, including cardiovascular disease and diabetes. Its long-term goals are to investigate:
- the efficacy and mechanisms by which novel exercise and diet interventions ameliorate disease risk;
- the individual responses to these exercise and diet interventions; and
- the impact of metabolic health improvement independent of obesity reversal.
At present, the EMDR has the following grants:
- a Tobacco-Related Disease Research Program (TRDRP) New Investigator Award to investigate the effects of resistance training on cardiovascular risk and insulin sensitivity in smokers;
- an NIH grant from NHLBI to investigate cardiovascular risk in Mexican Americans and the effects of lifestyle modification in this same population; and
- an NIH grant from NIDDK to investigate the efficacy and mechanisms by which a low-glycemic load diet and/or resistance training affects endothelial function, inflammation and glycemic variations.
In addition, the EMDR recently completed a Beginning Grant-in-Aid from the American Heart Association (AHA), Western States Affiliate to investigate the effects of resistance training on cardiovascular risk. These studies incorporate the use of randomized-controlled trial study design and measurement techniques such as DXA for body composition, MRI to determine visceral and organ fat, human monocyte and endothelial progenitor cell isolation and characterization, oral and intravenous glucose tolerance testing, tissue biopsy analyses and ultrasound to estimate brachial artery flow-mediated dilation and echocardiography. The EMDR is very resourceful and a proponent of collaborative research. Its intention is to continue to seek extramural funding that will foster continuous productivity for the EMDR laboratory.
Selected Cancer-Related Publications:
Roberts CK, Freed B, McCarthy WJ. Low aerobic fitness and obesity are associated with lower standardized test scores in children. J Pediatr. 2010 May;156(5):711-8, 718.e1. Epub 2010 Jan 25.
Roberts CK, Sindhu KK. Oxidative stress and metabolic syndrome. Life Sci. 2009 May 22;84(21-22):705-12. Epub 2009 Mar 9.
Sindhu RK, Koo JR, Sindhu KK, Ehdaie A, Farmand F, Roberts CK. Differential regulation of hepatic cytochrome P450 monooxygenases in streptozotocin-induced diabetic rats. Free Radic Res. 2006 Sep;40(9):921-8.
Roberts CK, Barnard RJ. Effects of exercise and diet on chronic disease. J Appl Physiol. 2005 Jan;98(1):3-30.
Roberts CK, Won D, Pruthi S, Kurtovic S, Sindhu RK, Vaziri ND, Barnard RJ. Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9, and monocyte chemotactic activity in men with metabolic syndrome factors. J Appl Physiol. 2006 May;100(5):1657-65. Epub 2005 Dec 15.