The primary focus of Dr. Denis Evseenko's research is the ontogenesis of connective tissue in humans. Specifically, his team is investigating the generation of cartilage-committed progenitors from human pluripotent and mesenchymal stem cells, with an ultimate goal to develop new therapeutic strategies in patients with osteoarthritis. In addition, Evseenko is developing antifibrotic therapies for prevention of fibrocartilage formation during regeneration/repair of articular cartilage defects, and dissecting the role of ABC xenobiotic transporters in stem cells and progenitors.
Selected Cancer-Related Publications:
Evseenko D, Zhu Y, Schenke-Layland K, Kuo J, Latour B, Ge S, Scholes J, Dravid G, Li X, MacLellan WR, Crooks GM. Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13742-7. Epub 2010 Jul 19.
Evseenko D, Schenke-Layland K, Dravid G, Zhu Y, Hao QL, Scholes J, Wang XC, Maclellan WR, Crooks GM. Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly. Stem Cells Dev. 2009 Jul-Aug;18(6):919-28.
Evseenko DA, Paxton JW, Keelan JA. Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factors. Drug Metab Dispos. 2007 Apr;35(4):595-601. Epub 2007 Jan 19.
Evseenko DA, Murthi P, Paxton JW, Reid G, Emerald BS, Mohankumar KM, Lobie PE, Brennecke SP, Kalionis B, Keelan JA. The ABC transporter BCRP/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction. FASEB J. 2007 Nov;21(13):3592-605. Epub 2007 Jun 26.
Evseenko DA, Paxton JW, Keelan JA. ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast. Am J Physiol Regul Integr Comp Physiol. 2006 May;290(5):R1357-65. Epub 2005 Dec 1.