Dr. Marta Epeldegui’s research for several years has focused on better elucidating the immunopathogenesis of HIV/AIDS, especially that of AIDS-associated lymphoma. Her Ph.D. focused on the role of activation-induced cytidine deaminase (AID) in driving oncogenic molecular changes in B cells, and on the induction of B cell activation by HIV virions, defining the role of CD40 ligand in this process. Currently, she is studying the association of immune activation in the development of HIV infection-associated lymphoma.
Selected Cancer-Related Publications:
Guo Y, Siewe B, Epeldegui M, Detels R, Landay AL, Martinez-Maza O. TLR2-activated B cells are phenotypically similar to the abnormal circulating B cells seen preceding the diagnosis of AIDS-related NHL diagnosis. J Acquir Immune Defic Syndr. 2013 Oct 1;64(2):204-10. doi: 10.1097/QAI.0b013e31829d4d50.
Epeldegui M, Thapa DR, De la Cruz J, Kitchen S, Zack JA, Martinez-Maza O. CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes. PLoS One. 2010 Jul 6;5(7):e11448. doi: 10.1371/journal.pone.0011448.
Epeldegui M, Vendrame E, Martinez-Maza O. HIV-associated immune dysfunction and viral infection: role in the pathogenesis of AIDS-related lymphoma. Immunol Res. 2010 Dec;48(1-3):72-83. doi: 10.1007/s12026-010-8168-8.
Epeldegui M, Breen EC, Hung YP, Boscardin WJ, Detels R, Martinez-Maza O. Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis. AIDS. 2007 Nov 12;21(17):2265-70.
Epeldegui M, Hung YP, McQuay A, Ambinder RF, Martinez-Maza O. Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations. Mol Immunol. 2007 Feb;44(5):934-42. Epub 2006 May 26.