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Arjun Deb, M.D.
Arjun Deb, M.D.


Internal medicine
Cardiovascular disease

General Information:



Associate Professor, Department of Medicine, Cardiology
Member, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research
Member, UCLA Molecular, Cellular and Integrative Physiology Program
Member, David Geffen School of Medicine Cell and Developmental Biology Program
Member, JCCC Cancer and Stem Cell Biology Program Area

Hospital Affiliation(s):

Ronald Reagan UCLA Medical Center


Cardiology, Duke University Medical Center, 2005 - 2006
Cardiovascular Disease, Mayo Clinic, 2002 - 2005
Internal Medicine, Mayo Clinic, 2000 - 2002
Internal Medicine, Mayo Clinic, 1999 - 2000
Medical Degree:
M.B.B.S., Calcutta Medical College, 1997


Board Certification(s):
Cardiovascular Disease, American Board of Internal Medicine, 2005
Internal Medicine, American Board of Internal Medicine, 2002, 2012

Contact Information:

(310) 825-9911

Practice Information:

Clinical Interest(s):
Cardiovascular disease

Scientific Interest(s):

Dr. Arjun Deb’s laboratory is interested in understanding how progenitor cells residing in tissues interact with scar-forming cells in regulating an injury response. Dysregulated wound healing is seen in many organs such as the heart and brain after acute or chronic injury and cancer itself is associated with an altered tissue response. Using murine models of heart and other organ injury, the Deb lab investigates how the response of scar-forming cells can be manipulated to alter scarring and enhance repair and regeneration of tissues. The role of stromal cells in altering the response to a tissue following malignant transformation is another evolving area of investigation in his laboratory.

Selected Cancer-Related Publications:

Duan J, Lee Y, Jania C, Gong J, Rojas M, Burk L, Willis M, Homeister J, Tilley S, Rubin J, Deb A. Rib fractures and death from deletion of osteoblast Beta-catenin in adult mice is rescued by corticosteroids. PLoS One. 2013;8(2):e55757. doi: 10.1371/journal.pone.0055757. Epub 2013 Feb 5.

Gherghe CM, Duan J, Gong J, Rojas M, Klauber-Demore N, Majesky M, Deb A. Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF-dependent manner. FASEB J. 2011 Jun;25(6):1836-43. doi: 10.1096/fj.10-172981. Epub 2011 Feb 14.

Duan J, Gherghe C, Liu D, Hamlett E, Srikantha L, Rodgers L, Regan JN, Rojas M, Willis M, Leask A, Majesky M, Deb A. Wnt1/Beta-catenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J. 2012 Jan 18;31(2):429-42. doi: 10.1038/emboj.2011.418. Epub 2011 Nov 15.

Deb A, Patterson C. Hard luck stories: the reality of endothelial progenitor cells continues to fall short of the promise. Circulation. 2010 Feb 23;121(7):850-2. doi: 10.1161/CIR.0b013e3181d4c360. Epub 2010 Feb 8.

Deb A, Davis BH, Guo J, Ni A, Huang J, Zhang Z, Mu H, Dzau VJ. SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a. Stem Cells. 2008 Jan;26(1):35-44. Epub 2007 Oct 4.